Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria.

نویسندگان

  • Karen F Novak
  • William J Diamond
  • Sreenatha Kirakodu
  • Rebecca Peyyala
  • Kimberly W Anderson
  • Ronald C Montelaro
  • Timothy A Mietzner
چکیده

The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 51 5  شماره 

صفحات  -

تاریخ انتشار 2007